Evaluation of Zidovudine recommended doses in HIV - 1 infected 1 children : a population pharmacokinetics study
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چکیده
3 Floris Fauchet a,b (#),PharmD, Jean-Marc Treluyer , MD, PhD , Pierre Frange, MD, 4 Saik Urien , MD, PhD, Frantz Foissac , PhD,, Naim Bouazza , PhD , Sihem Benaboud , 5 PharmD, PhD, Stephane Blanche, MD, Déborah Hirt , PharmD, PhD 6 7 a EA 3620 Université Paris Descartes, Sorbonne Paris Cité, France, 8 b Unité de Recherche Clinique, AP-HP, Hôpital Tarnier, Paris, France, 9 c Service de Pharmacologie Clinique, AP-HP, Groupe Hospitalier Paris Centre, France, 10 d CIC-0901 Inserm, Cochin-Necker, Paris, France, 11 e Unité d′immunologie, hématologie et rhumatologie pédiatriques, Hôpital Necker, APHP, France 12 13 Corresponding author: 14 Floris Fauchet, Unité de Recherche Clinique, AP-HP, Hôpital Tarnier 89 rue d’Assas, 75006 15 Paris, France 16 Email : [email protected] 17 18 Running title: ZDV Population pharmacokinetics 19 20 21 22 Copyright © 2013, American Society for Microbiology. All Rights Reserved. Antimicrob. Agents Chemother. doi:10.1128/AAC.00911-13 AAC Accepts, published online ahead of print on 22 July 2013
منابع مشابه
Pharmacokinetics of Zidovudine Dosed Twice Daily According to World Health Organization Weight Bands in Ugandan HIV-infected Children
Data on zidovudine pharmacokinetics in children dosed using World Health Organization weight bands are limited. About 45 HIV-infected, Ugandan children, 3.4 (2.6-6.2) years, had intensive pharmacokinetic sampling. Geometric mean zidovudine AUC0-12h was 3.0 h.mg/L, which is higher than previously observed in adults, and was independently higher in those receiving higher doses, younger and underw...
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OBJECTIVE This study examined the impact of the full 3-arm zidovudine regimen on the perinatal transmission of human immunodeficiency virus type 1 (HIV-1) using population-based data. METHODS We retrospectively ascertained information on zidovudine prescription and other characteristics of HIV-infected pregnant women and children for birth cohort years 1993, 1995, 1996, and 1997 using HIV/acq...
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تاریخ انتشار 2013